custom alerts on thinkorswim. only at td ameritrade. is depression more than sadness? ♪ it's a tangle of multiple symptoms. ♪ ♪ trintellix (vortioxetine) is a prescription medicine for depression. trintellix may start to untangle or help improve the multiple symptoms of depression. for me, trintellix made a difference. tell your healthcare professional right away if your depression worsens, or you have unusual changes in mood, behavior or thoughts of suicide. antidepressants can increase these in children, teens, and young adults. trintellix has not been studied in children. do not take with maois. tell your healthcare professional about your medications, including migraine, psychiatric and depression medications to avoid a potentially life-threatening condition. increased risk of bleeding or bruising may occur especially if taken with nsaid pain relievers, aspirin, or blood thinners. manic episodes or vision problems may occur in some people. may cause low sodium levels. the most common side effects are nausea, constipation and vomiting. trintellix did not have